The antimicrobial and wound healing effect of Aloe Vera in induced diabetic rats

The antimicrobial and wound healing effect of Aloe Vera in induced diabetic rats

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The study was conducted on sixteen welding sweater streptozotocin-induced diabetic rats to investigate whether the topical application of Aloe Vera gel and alcoholic Aloe Vera leaf extract could improve the wound healing in diabetic rats.The rats were weight, matched, and placed into four groups 4 rats of each group.Full-thickness circular skin wound (2cm in diameter) was experimentally created dorsal to the neck area of each rat.Animals in a group (1) left without dressing as a control group.

Animals in a group (2 and 3) were treated topically with Aloe Vera gel (100%) and alcoholic Aloe Vera leaf extracts (100%) respectively, while the animals of a group (4) were treated with povidone-iodine (4%).Treated groups were dresses twice daily for 14 successive days.The treated wound in groups 2, and 3 were significantly healed faster in comparison to the wound of the control group.The effect produced by the Aloe Vera with reference to the wound contraction, wound closure, decreased in surfaces area of the wound, and tissue regeneration at the wound site.

Histologically wounds treated with Aloe Vera show increase in macrophages, fibroblast migration, collagen regeneration, and epithelialization compared with the control group.The wet, dry granulation tissue weight and hydroxyproline content increased significantly when compared caruso rhodiola to control.Aloe Vera was seen exhibited antimicrobial activity against some pathogenic microorganism.Aloe Vera have strong wound healing property and effective as topical preparation and formulated as fairly economical therapeutic agent for wound management.